Pezuela was in Spain's gazetteers[6] until Puerto Rico was ceded by Spain in the aftermath of the Spanish–American War under the terms of the Treaty of Paris of 1898 and became an unincorporated territory of the United States.

In 1899, the United States Department of War conducted a census of Puerto Rico finding that the population of Pezuela barrio was 1,010.

In late 2019, 12 landslides occurred in one month's time as a result of heavy rainfall and some homes were in danger of collapsing near PR-131.

Residents stated the problem was caused by years of inaction to correct and clear waterways after Hurricane Maria, which struck in 2017.

[13] Barrios (which are, in contemporary times, roughly comparable to minor civil divisions)[14] and subbarrios,[15] in turn, are further subdivided into smaller local populated place areas/units called sectores (sectors in English).