Phanom Phrai (Thai: พนมไพร, pronounced [pʰā.nōm pʰrāj]; Northeastern Thai: พนมไพร, pronounced [pʰā.no᷇m pʰa᷇j]) is a district (amphoe) in the southeastern part of Roi Et province, northeastern Thailand.

Neighboring districts are (from the southwest clockwise): Nong Hi, Suwannaphum, At Samat, Selaphum of Roi Et Province; Mueang Yasothon, Kham Khuean Kaeo, Maha Chana Chai of Yasothon province; and Sila Lat of Sisaket province.

The district is divided into 13 sub-districts (tambons), which are further subdivided into 160 villages (mubans).

Missing numbers are tambons which now form Nong Hi District.

This Roi Et Province location article is a stub.