[5] Between conventions, the executive power of the fraternity is vested in a grand council composed of seven members who all reside in the same vicinity.

[5] The fraternity's periodical, Phi Rho Sigma Journal, began in January 1900.

[2][6] Its first editor was Dr. T. B. Swartz of the Alpha chapter; he served in this capacity for four years.

[11] The five districts included Eastern (Lambda), Erie (Kappa, Nu, Phi, Rho, Sigma, Skull and Septre, Upislon, and Zeta), Chicago (Alpha, Beta, Gamma, Omicron, and Pi), Mississippi (Eta, Theta, Iota, Mu, and Tau), and Pacific (Delta).

[11] On April 17, 1911, Phi Rho Sigma absorbed Alpha Omega Delta, a former national fraternity that had a remaining chapter at the University of Buffalo.

[1] In 1960, the grand chapter established national awards in the form of gold medals that are given at the biennial meeting.

In 1973, the fraternity changed its name to Phi Rho Sigma Medical Society and started accepting women as members.

[2][16][17] Some names reflect the chapter's origin as a previous local fraternity.