His senior year of football ended in the second round to Palisade High School; in that match-up, he played against another two-time All-State selection, Matt Popick.

[5] Enrolling at OU in January 2007, Loadholt made an immediate impact for the Sooners, as he started all 14 games at left tackle and logged 740 plays with 104 knockdowns.

He received All-Big 12 first team honors by the Dallas Morning News and an All-American honorable mention by Sports Illustrated In his senior year, Loadholt played left tackle in an offensive line that allowed 11 sacks all season, the third-lowest total of any team in the country, in 476 passing attempts.

[6] Protecting quarterback Sam Bradford, who threw 48 touchdown passes and went on to win the 2008 Heisman Trophy, and leading the way for DeMarco Murray and Chris Brown, who both ran for more than 1,000 yards, Loadholt helped the 2008 Sooners to become the highest-scoring team in college football's modern era.

For his first-year performance, he was named to the NFL All-Rookie team by Sporting News and PFWA as he helped the Vikings offense rank No.

He helped pave the way for Adrian Peterson to rush for 1,298 yards and break the 100-yard mark 5 times during the season.

In 2011, Loadholt joined fellow offensive line teammate Charlie Johnson as the only Vikings linemen to start all 16 games during the season, helping Adrian Peterson break the 100-yard mark in 3 games during the season with fullback Toby Gerhart and quarterback Joe Webb each breaking the 100-yard plateau once during the year.

Loadholt was part of a Vikings offensive line that started all 16 games and a playoff contest as well as a unit that helped pave the way for Adrian Peterson to notch the 2nd-best rushing season in NFL history with 2,097 yards en route to earning NFL MVP.

In the Vikings opening win over the St. Louis Rams, Loadholt anchored the right side of the offensive line that paved the way for wide receiver Cordarrelle Patterson to run for 102 yards, the highest rushing output by a non-running back in team history.

The Unit was one of five offensive lines that didn't allow its opponents to record a sack in the opening week of the 2014 season.

On August 15, 2015, Loadholt tore his Achilles tendon during the Vikings' first preseason game against the Tampa Bay Buccaneers.