He collaborated with Emmanuel Tzanes on several pieces while he was in Corfu, in the Ionian Islands.

He was briefly affiliated with the famous Greek church in Venice San Giorgio dei Greci.

Skoufos most popular works were the Stoning of St Stephen and the Virgin in the Temple.

Skoufos fled to the Ionian Islands and awaited permission to travel to Venice.

[5] In 1660, Emmanuel Tzanes became the parish priest of the Greek Orthodox Church San Giorgio Dei Greco replacing Skoufos.

By 1665, the Venetian State granted him the monastery of Panagia Laurentaina on the island of Zakynthos.

He requested permission to leave the church to his nephew Parthenios Skoufos.

Clearly, Skoufos influenced many artists including Emmanuel Tzanes whom he collaborated with on several occasions.

Comparing Theodore Poulakis Adam and Eve to Skoufos Forty Holy Martyrs.

Skoufos technique also has its place in the early formation of the Heptanese School.

One artist that Skoufos's work closely resembles is Victor (iconographer).