[citation needed] When Calandio, the Chalcedonian patriarch of Antioch, was expelled by the Miaphysite Peter the Fuller in 485, Philoxenus was ordained bishop of Mabbug.
[citation needed] With the support of Emperor Anastasius I Dicorus, the Miaphysites ousted Flavian II in 512 and replaced him with their partisan Severus of Antioch.
We know that in 498 he was staying at Edessa; in or about 507, according to Theophanes, he was summoned by the emperor to Constantinople; and he finally presided at a synod at Sidon which was the means of procuring the replacement of Flavian by Severus.
Of the chief monument of his scholarship – the Philoxenian version of the Bible – only the Gospels and certain portions of Isaiah are known to survive (see William Wright, Syr.
Of the excellence of his style and of his practical religious zeal we are able to judge from the thirteen homilies on the Christian life and character which have been edited and translated by E. A. Wallis Budge (London, 1894).
In these he holds aloof for the most part from theological controversy, and treats in an admirable tone and spirit the themes of faith, simplicity, the fear of God, poverty, greed, abstinence and unchastity.