In 1986, the hospital was at the center of a criminal case after a GBI investigation following an unusually high percentage of cardiac arrests.

Potassium chloride was injected into a bag of frozen plasma which was then introduced to a patient's body.

[3] In 2010, the facility bought out the area's only other hospital, Palmyra Medical Center, for $195 million.

[4] Because of the merger, the hospital agreed to a settlement with the Federal Trade Commission in 2013 that for the next 10 years, PPMH and the Hospital Authority of Albany-Dougherty County, without first notifying the FTC, would not acquire another medical facility within Dougherty, Lee, Baker, Terrell, Worth, and Mitchell Counties.

[5] On June 7, 2018, the hospital announced its president and CEO Joel Wernick would be retiring in May 2019 after 30 years in that position.