In August 2011, the community hospital's executive Board agreed to affiliate with Piedmont Healthcare.

In 2006, Henry Medical Center completed its North Tower, expanding its operations to include 215 beds.

In July 2010, Henry Medical Center opened the Henry Radiation Oncology Center in a joint venture with Radiation Oncology Services.

In early 2024, the hospital began construction on a new patient tower.

In addition, the expansion includes adding three new operating rooms bringing the hospital to a total of 14, constructing a new kitchen and dining area, and building a new central energy plant.