[6] Further studies found that sensitivity to phosphatidylcholine levels causes PCTP to interact with select enzymes, promoting their activation.

[9] Protein kinase C phosphorylation promotes localization of PCTP to the mitochondrion where it may activate Them2.

X-ray crystallography shows that this domain forms a pocket that can bind a single molecule of phosphatidylcholine.

This subfamily consists of PCTP, StarD7, StarD10 and collagen type IV alpha-3-binding protein or StarD11, all of which bind phosphatidylcholine except for StarD11 which prefers ceramide.

[13][14] Loss of PCTP in fasting mice alters the sensitivity of the liver to insulin, reducing glucose and free fatty acid levels.