Phosphocholine is an intermediate in the synthesis of phosphatidylcholine in tissues.

Phosphocholine is made in a reaction, catalyzed by choline kinase, that converts ATP and choline into phosphocholine and ADP.

In nematodes and human placentas, phosphocholine is selectively attached to other proteins as a posttranslational modification to suppress an immune response by their hosts.

[1][2] It is also one of the binding targets of C-reactive protein (CRP).

[3] Thus, when a cell is damaged, CRP binds to phosphocholine, beginning the recognition and phagocytotic immunologic response.