Phthiotis and Phocis Prefecture (Greek: Νομός Φθιώτιδος και Φωκίδος) was a prefecture of Greece.
It was first established in 1833 as the Phocis and Locris Prefecture (Νομός Φθιώτιδος και Λοκρίδος) but abolished in 1836 and reconstituted in 1845 under its later name.
With the annexation of Thessaly by Greece in 1881, the prefecture's territory came to include the Domokos Province.
The prefecture finally ceased to exist in 1943, when it was again split up into Phthiotis and Phocis.
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