Phu Khat Wildlife Sanctuary (Thai: เขตรักษาพันธุ์สัตว์ป่าภูขัด; RTGS: Khet Raksa Phan Satpa Phu Khat) is a wildlife sanctuary in Nakhon Thai District of Thailand's Phitsanulok Province.

The sanctuary covers an area of 241 square kilometres (93 sq mi) and was established in 2017.

Phu Khat Wildlife Sanctuary is located about 100 kilometres (62 mi) northeast of city of Phitsanulok and 80 kilometres (50 mi) west of Loei town in Bo Pho, Na Bua, Nakhon Chum, Nam Kum and Yang Klon subdistricts, Nakhon Thai District of Phitsanulok Province.

[8] The sanctuary is located in Chat Trakan, Daeng, Lam Khwae Noi Fang Sai, Nam Phak and Noen Pheum forests of Nakhon Thai District of Phitsanulok Province.

[9] In the sanctuary are the following number of species: 29 mammals, 128 birds, 22 reptiles and 12 amphibians.