Umphang Wildlife Sanctuary (Thai: เขตรักษาพันธุ์สัตว์ป่าอุ้มผาง) is a wildlife sanctuary in Thailand site in the Umphang District of Tak Province, northwestern Thailand.

Places adjacent to Umphang Wildlife Sanctuary are (from the north clockwise): Myanmar, Mokro and Phop Phra District in Tak Province, Khlong Wang Chao National Park, Khlong Lan National Park, Mae Wong National Park, and Thung Yai Naresuan Wildlife Sanctuary.

[2] With an abundance of forests, this makes it the watershed of the Mae Klong River (as well as Khwae Yai River) that flows south to the provinces of Kanchanaburi, Ratchaburi and Samut Songkram.

Frequently spotted fauna, for example, clouded leopard, Malayan tapir, mainland serow, falcon, wreathed hornbill, great hornbill, Oriental darter, Indochinese tiger, Indian elephant, silvery lutung, northern pig-tailed macaque, include species of reptiles and amphibians, such as impressed tortoise, Asian forest tortoise, elongated tortoise, Burmese python, reticulated python, as well as an endangered species, Blyth's river frog.

There are multiple falls, streams and pools to bathe in and whilst the most spectacular time to visit is between July and November, water flows throughout the year.