She rose to fame at the age of 17 after the success of the song "Nỗi buồn gác trọ" (by Hoai Linh and Manh Phat) in 1962, "Những đồi hoa sim" in 1964 (by Dzũng Chinh, who used a poem by Hữu Loan as lyrics), and "Tạ từ trong đêm" in 1965 (by Trần Thiện Thanh).
Phuong Dung sings about love songs associated with wartime as seen in the songs: "The Sim flower hill" (Dzũng Chinh and Hữu Loan), "Nỗi buồn gác trọ" (Manh Phat and Hoai Linh), "Tạ từ trong đêm" (Tran Thien Thanh), "Khúc hát ân tình" (Xuân Tiên và Y Vân), "Đố ai" (Phạm Duy), "Sương lạnh chiều đông" (Mạnh Phát), "Tím cả rừng chiều" (Thu Hồ), "Vọng gác đêm sương" (Mạnh Phát), "Cánh buồm chuyển bến" (Minh Kỳ), "The Winter Night's Sorrow" (Anh Minh), "Sắc hoa màu nhớ" (Nguyễn Văn Đông), "Biết đâu tìm" (Hoàng Thi Thơ), "Còn mãi những khúc tình ca" (Quốc Dũng).
Around the end of 2014, Phuong Dung was invited as judge for the music competition Solo cùng Bolero and continued on the talent show into 2016.
[2][3][4] Phuong Dung established the charity "See The Light" which specializes in helping the poor in Vietnam by raising money to build houses, and schools.
In addition to her work with eye treatment, she participated in charities to help poor students, as well as flood and disaster relief.