Physa mezzalirai is an extinct fossil species of air-breathing freshwater snail, an aquatic pulmonate gastropod mollusc belonging to the family Physidae.

This species is characterized by its small sinistral (left-handed) shell, a common feature in this family.

Physa mezzalirai dates back to the Turonian to Santonian-aged Adamantina Formation (Upper Cretaceous Bauru Group), in São Paulo state, Brazil.

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