Physalaemus nattereri (common name: Cuyaba dwarf frog) is a frog native to central and southeastern Brazil and eastern Bolivia and Paraguay.

The 3–4 cm frog lifts its rear end when threatened, startling predators.

[4] A study in Bodoquena (in the Mato Grosso do Sul state of Brazil) found Physalaemus nattereri to be an explosive breeder, with most of the reproductive activity occurring within a few days after heavy rainfall.

Egg clutches were deposited in the margins of temporary ponds.

It inhabits savannas and grasslands in the Cerrado biome and is found on the ground near standing and temporary waterbodies, such as ponds and swamps.