Picinisco (locally Pecenische) is a comune (municipality) in the Province of Frosinone in the Italian region Lazio, located about 120 kilometres (75 mi) east of Rome and about 45 kilometres (28 mi) east of Frosinone.

It is included in the Valle di Comino and National Park of Abruzzo, Lazio e Molise.

Picinisco was already inhabited, by Sabellian peoples, before it was subsumed into the expanding Roman Empire over two thousand years ago.

The first surviving written record of Picinisco dates from the middle of the 12th century, when King Roger II of Sicily defined through a decree the territorial limits of the adjacent town of Atina.

[3] Included among many of the Italian surnames that originate from around Picinisco are, Arcari, Boni, Capaldi, Capocci, Cervi, Conetta, Coppola, Crolla, Dalsasso, D'Ambrosio, DiCiacca, De Luca, De Marco, Marini, Pacitti, Pelosi, Pia, Tartaglia and Ventre.