Picture Rocks is the birthplace of Warren Sprout, who won a shooting gold medal at the 1912 Olympics.

[6] The earliest settlers arrived in 1773 and observed Indian pictographs (no longer extant) in the Muncy Creek valley.

The borough occupies the site of a Munsee Indian village, evidenced by arrowheads and other relics found in the vicinity of the creek.

The Province of Pennsylvania issued the first warrant for property in the Picture Rocks area to Henry Rody on June 3, 1773.

The land remained largely undeveloped passing through several hands until it was sold in 1848 to A. R. Sprout and Amos Burrows.

This factory, the first of its kind in the area, caused a stir among local carpenters who believed that the ready made building materials would curtail their craft.

The prohibitionist organizers of the town required persons purchasing lots in Picture Rocks to sign an agreement stating that they would not open a saloon or engage in the trafficking of liquor.

A traveling minister arrived in Picture Rocks one Saturday evening and found the school to be unfit for Sunday gatherings.

The stately homes built by the Burrows and Sprout families remained along Center Street and were identified by their square shape with low pitched roofs some with a widow's watch.

Borough resident John Wesley Little achieved international fame for his watercolor landscapes and images of rural farms and animals.

According to the United States Census Bureau, the borough has a total area of 0.9 square mile (2.4 km2), all land.

History of Lycoming County, Pennsylvania: including its aboriginal history; the colonial and revolutionary periods; early settlement and subsequent growth; organization and civil administration; the legal and medical professions; internal improvement; past and present history of Williamsport; manufacturing and lumber interests; religious, educational, and social development; geology and agriculture; military record; sketches of boroughs, townships, and villages; portraits and biographies of pioneers and representative citizens, etc.