It serves domestic flights within Mexico for the Eagle Pass-Piedras Negras binational metropolitan area, the northern Coahuila region and Southern Texas.

Passengers traveling to destinations in the United States typically utilize the larger San Antonio International Airport.

Aeroméxico Connect operated a daily flight to Monterrey until the winter of 2009, which was canceled due to the replacement of its Saab 340 aircraft with Embraer ERJ 145 jets.

After two years without commercial flights, on November 3, 2010, Aeromar commenced operations in the city with the Piedras Negras-Monterrey route.

The departures concourse includes two gates with direct access to the apron, allowing passengers to board their planes by walking to the aircraft.