Pier Luigi Luisi (born 23 May 1938) is an Italian chemist and academic.

He received the "professor emeritus" title from the Swiss Federal Institute of Technology (ETHZ).

Luisi then moved to the Roma Tre University as a Professor of Biochemistry, where he worked until 2015.

In 1985, Luisi founded the Cortona Week, an international summer school.

Luisi graduated with a chemistry degree from the Scuola Normale Superiore di Pisa.