He has one older sister, Maria Elvira "Marina" (born in 1966)[1][2] and three younger half-siblings from his father's second marriage: Barbara, Eleonora and Luigi.

[5][6] Pier Silvio Berlusconi embarked on his professional experience in 1992 within Publitalia, the group's advertising agency, before transitioning to roles within Italia 1 television network.

Since April 2000, Pier Silvio Berlusconi has held the role of Vice President at Mediaset, now known as MFE, and assumed the CEO position in 2015.

[8] During his tenure, on 8 April 2016, Pier Silvio Berlusconi finalized an agreement with Vivendi aimed at fostering new projects and an equal exchange of 3.5% shares between the parent companies.

These initiatives included the establishment of a European major for content creation on an international scale, bolstered by distribution across the TV networks of both groups in Italy, France and Spain.

Additionally, plans were set in motion for a pan-European platform for streaming on-demand content, alongside the integration of Mediaset Premium into a large international pay TV network.

[21] Despite receiving favorable support from Forza Italia, Fratelli d'Italia and Lega, according to polls in the summer of 2023[22] he decided against entering politics to succeed his father.