Mahony was educated at Rugby School and at Magdalen College, Oxford, where he did not take a degree, but established an Irish Home Rule club and formed a friendship with his later Parliamentary colleague J. G. Swift MacNeill.
An ancient stone cross taken (with permission) from the Bulgarian monastery at Bansko stands over Alice's grave in the church cemetery at Ballinure in West Wicklow, Ireland.
[4] At the general election of 1892, Mahony was defeated in North Meath by the prominent land campaigner Michael Davitt, who had taken a particularly strong and clericalist line against Parnell from early in the crisis, by 54% to 46%.
He stood as Parnellite candidate for Dublin St Stephen's Green at a by-election in September 1895 but failed to unseat the Liberal Unionist member, William Kenny.
In the general election of 1918 he fought West Wicklow for the Irish Parliamentary Party but lost to the Sinn Féin candidate Robert Barton by the particularly wide margin of more than four to one.
In 1903 O’Mahony travelled to Bulgaria to undertake relief work among orphans who had fled from Turkish massacres during the Ilinden-Preobrazhenie Uprising, and in 1904 opened St Patrick's Orphanage in Sofia.
Later in the year and resigned as Deputy Lieutenant of County Wicklow and as a magistrate in protest against British policy in the Irish War of Independence then in progress.
In commemoration of his relationship with the Bulgarian Orthodox church, in 1909, Pierce commissioned a fresco by Iliev Gannin, depicting Saints Methodius, Cyril and Patrick.
[citation needed] His son Dermot O'Mahony was a Cumann na nGaedheal and Fine Gael member of the Dáil Éireann for Wicklow from 1927 to 1938.