Piero Antonio Luisi (born 13 March 1987) is a Venezuelan former professional tennis player.

The son of an Italian-born father, Luisi was raised in Valencia, Carabobo.

[2] While competing on the professional tour he reached a career best singles ranking of 471.

During his career he appeared in a total of 12 Davis Cup ties for Venezuela, debuting in 2006.

He won his only ITF Futures singles tournament in 2009 and featured in the qualifying draw for the 2010 U.S. Men's Clay Court Championships.