The 2010 U.S. Men's Clay Court Championships was a men's tennis tournament played on outdoor clay courts.

It was the 42nd edition of the U.S. Men's Clay Court Championships, and was an ATP World Tour 250 event.

It took place at River Oaks Country Club in Houston, Texas, United States, from April 5 through April 11, 2010.

Unseeded Juan Ignacio Chela won the singles title.

The following players received wildcards into the main draw: The following players received entry via qualifying: Juan Ignacio Chela defeated Sam Querrey, 5–7, 6–4, 6–3 Bob Bryan / Mike Bryan defeated Stephen Huss / Wesley Moodie, 6–3, 7–5