Pierre-Louis Leysin (born in Aosta in the Dauphiné on 2 May 1721 – died in Munich in Bavaria on 26 August 1801) was a French clergyman who was the 81st and last Archbishop of Embrun from 1767 to 1790.
Pierre-Louis Leyssin was the son of François-Louis (died 22 July 1783), Knight of the Order of St. Louis, Baron Domeyssin, co-lord of Culloz and his wife Françoise-Marie de la Martinière.
Commendatory of the royal abbey of Saint-Nicolas Septfontaines in the diocese of Reims, he was chosen as vicar general by Claude-Joseph-Mathias Barral, bishop of Troyes.
Ignace Caseneuve was appointed constitutional bishop of Hautes-Alpes department in March 1791 and crowned in Paris on 3 April.
He then fled to the Sardinian states where he resided until the French invasion in 1796 and finally he moved to Munich in Bavaria, where he died in 1801, the year the Concordat permanently removes the archbishop of Embrun.