He played college football for the Lindenwood Lions and Washburn Ichabods before being selected by the Cleveland Browns in the fourth round of the 2014 NFL draft.

He has also played for the San Diego Chargers, Indianapolis Colts, New York Jets, Baltimore Ravens, and Tampa Bay Buccaneers.

[2][3] Desir attended Francis Howell Central High School in Cottleville, Missouri, where he was an all-state selection at defensive back.

In 2009, he was named first team all-Mid-America Intercollegiate Athletics Association (MIAA) after leading the conference with seven interceptions and 13 passes defended, and finished the season with 33 total tackles.

In 2010, he recorded 46 tackles, including 5.5 for loss, nine pass deflections, one forced fumble, and five interceptions, earning himself second team all-MIAA honors.

[13] Head coach Mike Pettine named Desir the fourth cornerback on the depth chart to begin the regular season, behind Joe Haden, Buster Skrine, and Justin Gilbert.

On December 21, 2014, Desir earned his first career start and collected a season-high seven solo tackles and broke up two pass attempts during a 17–13 loss at the Carolina Panthers in Week 16.

[16] During training camp, Desir competed for a roster spot as the third cornerback against Gilbert, Charles Gaines, Robert Nelson, and K'Waun Williams.

[17] Head coach Mike Pettine named Desir the fourth cornerback on the Browns' depth chart to begin the regular season.

[16] On January 4, 2016, the Browns fired head coach Mike Pettine and general manager Ray Farmer after they finished with a 3–13 record.

[21] Throughout training camp, Desir competed for a roster spot as a backup cornerback against Gilbert, Charles Gaines, Trey Williams, and Jamar Taylor.

[25] Head coach Mike McCoy named Desir the fifth cornerback on the Chargers' depth chart to begin the regular season, behind Jason Verrett, Brandon Flowers, Casey Hayward, and Craig Mager.

[31] Throughout training camp, Desir competed to be a backup cornerback against Mike Tyson, Tramaine Brock, Neiko Thorpe, Demetrius McCray, and DeAndre Elliott.

[34] Head coach Chuck Pagano named Desir the sixth cornerback on the Colts' depth chart, behind Vontae Davis, Rashaan Melvin, Nate Hairston, Quincy Wilson, and Kenny Moore II.

Desir intercepted a pass by Steelers' quarterback Ben Roethlisberger, that was originally intended for wide receiver Martavis Bryant, during the first quarter.

[40] Head coach Frank Reich named Desir the third cornerback on the Colts' depth chart to begin the regular season, behind Moore and Hairston.

[51] In Week 4 against the Broncos on Thursday Night Football, Desir recorded two interceptions off of passes thrown by quarterback Brett Rypien, including a pick six, in the 37–28 loss.

They divorced in 2023[3] They have three children: Keeli, Kamryn, and Pierre, Jr.[66] In February 2021, he donated 10,000 meals to the Houston Food Bank during Winter Storm Uri, which put much of Texas out of power, water, and heat.