He played college football for the Nevada Wolf Pack and was selected by the Browns in the second round of the 2014 NFL draft.

During his NFL career, Bitonio has been named to seven Pro Bowls, two first-team and three second-team All-Pro teams.

In football, he was a two-time All-league selection and was the Moore League Lineman of the Year.

He led the league in the shot put, recording a top-throw of 15.39 meters at the 2009 CIF Southern Section Division 1 Prelims.

Bitonio was named to the 2020 All-Pro Team, along with three of his teammates: defensive end Myles Garrett, tackle Jack Conklin, and fellow guard Wyatt Teller.