The Pierson–Betts House is a historic residence located in Oskaloosa, Iowa, United States.

The house was built by Lewis B. Pierson, the long-time Superintendent of Buildings and Grounds for William Penn College.

[2] He built this modest, single-story, brick house in the 1930s as a place that he and his wife Lilly could retire.

It is Pierson's and Betts' association with the college in the context of the Quaker testimony in Oskaloosa that makes this house historic.

This article about a property in Mahaska County, Iowa on the National Register of Historic Places is a stub.