The Rock Island Passenger Depot is a historic building located in Oskaloosa, Iowa, United States.

The Chicago, Rock Island & Pacific Railroad arrived in town in 1876, and they built a frame combination depot on the north side of the tracks.

This depot replaced the original one in 1888 on the south side of the tracks, and it served ten passenger trains a day.

The depot is a single-story brick structure in the Stick-Eastlake style.

This article about a property in Mahaska County, Iowa on the National Register of Historic Places is a stub.