Du Toit plays as a lock or a flanker for the South Africa national team and the Toyota Verblitz in Japan Rugby League One.

[2] Du Toit was a member of the South Africa Under 20 team that won the 2012 IRB Junior World Championship.

[6] Du Toit has since become a regular for the Springboks and was a part of the South African team for the 2015 Rugby World Cup.

The following season saw Du Toit become a regular starter for South Africa, under new head coach, Allister Coetzee.

On 2 June 2018, Du Toit became the 60th captain of South Africa, as he led the Springboks out against Wales, losing the match 20–22.