After a rocky start in which he was sin-binned for a dangerous tackle on Blue Bulls full-back Jurgen Visser and subsequently suspended for Griquas' second match of the season,[6] Le Roux established himself as one of the top players in South African domestic rugby.

[8] He made his debut in Week 1 of the 2012 Super Rugby season as a half-time substitute for Dusty Noble as the Cheetahs narrowly lost 25–27 to the Lions in Johannesburg.

[13] In August 2016, English Premiership side Wasps announced Le Roux would join them in January 2017 after finishing his commitments with the Canon Eagles.

[16] On 4 July 2023, Le Roux returned to South Africa to join the Blue Bulls, where he began playing after the Springboks' World Cup campaign.

[17] He played the full 80 minutes of all three test matches against these teams with distinction, hardly faltering any time at full-back, and contributed to the try-making by joining the Springbok backline in sprints for the opponents' tryline.

He turned in a particularly impressive display in the 28-0 destruction of Scotland scoring one intercept try and setting up another immediately from the restart for team-mate JP Pietersen.

[26] On 14 June 2014, Le Roux produced a man-of-the-match performance to help South Africa beat Wales during the 2014 incoming tours, scoring a try and providing three assists.