Serving as minister of Finance in six cabinets throughout the middle of the 19th century, Van Bosse led many reforms that liberalised the Dutch economy.

In 1845, he was appointed referendary of the import and export rights department of the Ministry of Finance, he position he would retain for three years.

Under the premiership of Johan Rudolph Thorbecke, Van Bosse introduced reforms that liberalised the economy.

He reformed the coinage by introducing the silver standard and a simpler system of nickels, dimes, quarters, half guilders and rijksdaalders.

In 1860, Van Bosse returned to the House of Representatives for Zutphen, only to serve a third term as minister of Finance from 10 February to 1 June 1866.

[1][2] On 3 June 1868, Van Bosse started another term as minister of finance in a cabinet formed by Thorbecke as formateur.

Due to conflict in Aceh, disagreements within the cabinet and the House of Representatives regarding the Dutch East Indies and his tense relation with the Governor General of the colony, Van Bosse was unable to achieve much.