Pike Creek is a stream in Carter and Shannon counties in the Ozarks of southern Missouri.
[1] The source area of the stream lies just east of Bartlett and north of U.S. Route 60.
The stream course roughly parallels Route 60 as it passes Low Wassie and Fremont.
The stream enters Carter County east of Low Wassie.
Just north of Fremont the stream course includes several tight incised meanders as it passes the old Midco Iron Works site.