Route 19 is a long state highway in Missouri.

It then travels mainly south, forming an 8-mile concurrency with U.S. Route 54, 3 miles west of Farber.

It crosses the Missouri River on the Christopher S. Bond Bridge at Hermann.

It then forms a brief 1 mile concurrency with U.S. Route 50 at Drake.

The part from Drake north to US 54 east of Mexico was Route 45 from 1922 until about 1930.