Pikrolimni (Greek: Πικρολίμνη) is a former municipality in the Kilkis regional unit, Greece.

Since the Kallikratis Plan for local government reform was implemented in 2011, Pikrolimni is administrated as part and constitutes a municipal unit of the municipality of Kilkis.

[2] The municipal unit has an area of 164.06 km2, and its population in the 2021 census was 4,297, down from 7,395 in 2001.

[1][3] The seat of the municipality was Mikrokampos.

The namesake of the region, as well as its most famous attraction, is the salt lake Pikrolimni which has been historically important as a source of natron in antiquity and recognised to this day for its pelo- and balneotherapeutic properties.