The palace was erected from 1610 to 1630 by the Catholic nuncio and bishop of Novara, Ulpiano Volpi.
He commissioned the sober Renaissance-style design from the architect Sergio Venturi.
It houses collections whose core pre-19th-century works come from suppressed ecclesiastic institutions.
It contains a display of Paolo Giovio's portraits of illustrious men.
It houses items from the Como Cathedral, including stained glass windows, sculptures, tapestries and wooden models.