[1] The creek's watershed has an area of 30.7 square miles and is located in Columbia and Luzerne Counties.

It flows southeast for a few miles, entering a valley and receiving the tributaries Brish Run and Wasp Branch.

[5] 9 miles (14 km) upstream of its mouth, the elevation of Pine Creek is 1,040 feet (320 m) above sea level.

8 miles (13 km) upstream of the mouth, the elevation is 900 feet (270 m) above sea level.

[5] On average, the annual level of precipitation in the vicinity of Pine Creek ranges from 35 to 50 inches (89 to 127 cm).

[5] Communities in the watershed of Pine Creek include Cambria, New Columbus, and Fairmount Springs.

[8] The August 19, 1890 Wilkes-Barre tornado, passed by the creek, where it had a smell resembling sulfur.

[10] In the early 1900s, industries in the vicinity of Pine Creek included agriculture and timber.

[12] The Western Pennsylvania Conservancy has recommended the creation of riparian buffers along several miles of Pine Creek and its tributaries.