Pioneer Works is a nonprofit cultural arts center in the Red Hook neighborhood of Brooklyn, New York City that was founded by artist Dustin Yellin in 2012.

[1][2] Pioneer Works includes a large exhibition space, a garden, an artist-in-residency program, a class and lecture series, and a press, and "aim[s] to foster innovation in the performing and visual arts, music and science.

[1] Yellin's cousin Gabriel Florenz became the institution's founding artistic director,[7] and Sam Trimble served as lead architect for a 2011 renovation that added 100 windows.

[9] Five feet of water flooded the space, severely damaging the ground floor; many of those living and working nearby suffered extensive losses from the storm, and the building's reconstruction had to be started over.

The Scientific Controversies program has hosted geneticist George Church, oncologist Sidhartha Mukarjee, Nobel Prize winner Rainer Weiss, and evolutionary biologist Richard Dawkins.