Mann began her career in 2003, after signing a three-race contract with Manor Motorsport to race in the winter series of the British Formula Renault Championship.

In December 2009, after deciding to remain in Indianapolis and find a place in another team,[3] Mann confirmed that she would be joining Sam Schmidt Motorsports for the 2010 Indy Lights series.

On 1 March 2011, Mann tested for the Indianapolis-based IndyCar Series team Conquest Racing at Texas Motor Speedway,[5] and on 19 April, she announced that she would be piloting the No.

She sustained severe burns to her right little finger and was transported by ground ambulance to UMC Southern Nevada, where she was admitted for treatment and released the next day, pending later surgery.

The crash claimed the life of two-time winner of the Indianapolis 500 Dan Wheldon, and also sent J. R. Hildebrand to hospital with a bruised sternum.

Cyclops Gear, owned and founded by Mark Krause, partnered with Dale Coyne Racing for this event.

[13] In 2014, Mann qualified in 22nd position for the 98th Indianapolis 500 as the only female driver in the field and finished 24th (again out of 33) for Dale Coyne Racing and in partnership with Susan G.

[14] The partnership allowed race fans to donate for each lap Mann completed during the month of May, in support of ending breast cancer.

Although encountering an issue during one of the early pit stops, she completed 484 total laps for the month and finished the entire race.

She was selected by the Susan G. Komen foundation to be on "The List", along with former First Ladies Laura Bush and Betty Ford, and 29 other key public figures, for their efforts and support in fighting breast cancer.

[25] After finishing a career-best 18th place in the 100th running of the Indianapolis 500, Mann was also named by Autocar as one of the top 100 British Women in the Car Industry.

[34] In December 2012, Mann married Robert Gue, an engineer at Schmidt Peterson Motorsports who is the former race strategist for James Hinchcliffe.