The Pisa–Lucca railway (Italian: Ferrovia Pisa-Lucca) is a line that was built in 1846 connecting the Tuscan cities of Pisa and Lucca.

The line reached San Giuliano Terme on 29 September and Pisa on 15 November 1846, when regular train services commenced.

From its earliest days it was not a profitable railway and was declared bankrupt in 1854 and an auction was arranged for 1858 to sell its assets.

The Lucca–Pisa line was taken over by the Adriatic Network during the reorganisation of 1885, giving it a connection from Bologna and Florence to Livorno via Lucca and Pistoia.

The competing Mediterranean Network, established at the same time, was assigned the route from Florence to Livorno via Empoli and Collesalvetti.