Its building led to the conversion of the old Leopolda station (inaugurated in 1844) into a freight yard, which functioned until 1929, when it was closed permanently.

The whole Pisa Centrale complex was severely damaged during World War II and rebuilt with some changes to the original design.

The passenger station building is large and offers numerous services such as domestic and international ticketing, waiting room, baggage storage, three bars, pizzerias, fast food, cafeterias, three newsagents, tobacconist, pharmacy and other shops.

The main destinations are Florence, Genoa, Rome, Naples, Livorno, Lucca, La Spezia and Turin.

People mover to Pisa Airport, coaches to Collesalvetti, Cecina, Florence, Reggio Calabria and urban bus lines operate from the front of the station.