[1][3] P. ayeaye is found in the transition zone between cerrado (tropical woodland-savanna) and Atlantic semi-deciduous forest,[5] laying its eggs on leaves above streams or pools so the tadpoles, when hatched, fall into the water below.

[1] Pithecopus ayeaye is a medium-sized frog that can grow between 28.7 mm to 40 mm long and weigh from 1.89 g to 7.5 g.[6][2] The dorsal side is a bright green color, and the sides of its body and appendages have a distinctive network of black lines with circular reddish to orange spots.

[2] The reticulated leaf frog is native to South America and lives in the Espinhaco, Mantiqueira, and Canastra mountain ranges located in Brazil.

Most P. ayeaye breed on nights with sufficient rainfall to increase the likelihood that fertilization will occur.

Human-related threats include mining for materials in Brazil, fires that ravage the landscape, and pollution from industries and military operations.

[4] The International Union for Conservation of Nature classifies the reticulated leaf frog as critically endangered.

[4] While currently no specific conservation measures target this colourful amphibian, its occurrence in protected areas, such as the Parque Nacional da Serra da Canastra in the state of Minas Gerais and Parque Estadual das Furnas do Bom Jesus in the state of São Paulo, may provide it with some level of protection.