Large portions of the line have been abandoned; the only major pieces still in use are from Mingo Junction (west of Steubenville) to Columbus, operated by the Columbus and Ohio River Rail Road (Ohio Central Railroad System), and west of Terre Haute, operated by CSX Transportation as part of its St. Louis Line Subdivision.
Other existing pieces are from Rosslyn, Pennsylvania to Walkers Mill (Pittsburgh and Ohio Central Railroad), Weirton Junction, West Virginia to Mingo Junction (Norfolk Southern Railway Weirton Secondary), Columbus to London, Ohio (NS Dayton District), Clement, Ohio to Dayton (NS), just east of Richmond, Indiana (NS New Castle District), and from Indianapolis to Ben Davis, Indiana (CSX Crawfordsville Branch Subdivision).
[8] The Pittsburgh, Cincinnati and St. Louis Railway leased the Columbus, Chicago and Indiana Central Railway (the Indiana Central's successor) and the Little Miami in 1869, giving the PRR a line to Indianapolis (including an alternate route between Columbus and New Paris), fully operated by the PC&StL.
The entire line was operated by the Terre Haute and Indianapolis under lease[14] until 1905, when the two companies were merged into the Vandalia Railroad.
[17] The line passed to Penn Central Transportation in 1968 and Conrail in 1976, after which large portions were sold off or abandoned.