As of the 2020 United States Census, there were 868 people, 390 households, and 246 families residing in the town.

As of the census[5] of 2000, there were 1,144 people, 416 households, and 301 families residing in the town.

There were 474 housing units at an average density of 328.4 per square mile (126.8/km2).

22.4% of all households were made up of individuals, and 6.7% had someone living alone who was 65 years of age or older.

The Town of Plantersville is served by the Lee County School District.