Plastoquinone

Plastoquinone (PQ) is a terpenoid-quinone (meroterpenoid) molecule involved in the electron transport chain in the light-dependent reactions of photosynthesis.

[1] The benzoquinone and isoprenyl units are both nonpolar, anchoring the molecule within the inner section of a lipid bilayer, where the hydrophobic tails are usually found.

[2] Plastoquinone is reduced when it accepts two electrons from photosystem II and two hydrogen cations (H+) from the stroma of the chloroplast, thereby forming plastoquinol (PQH2).

[2] The cytochrome b6f protein complex catalyzes the electron transfer between plastoquinone and plastocyanin, but also transports the two protons into the lumen of thylakoid discs.

[2] There are additional plastoquinone binding sites within photosystem II (QC and possibly QD), but their function and/or existence have not been fully elucidated.

[10] SkQR1 and SkQ1 have also been proposed as a possible way to treat brain issues like Alzheimer's due to their ability to potentially fix damages caused by amyloid beta.

The reduction (from left to right) of plastoquinone (PQ) to plastosemiquinone (PQH . ) to plastoquinol (PQH 2 ).
The structure of photosystem II is shown above, with the flow of electrons detailed by the red arrows. Plastoquinone binding sites Q A and Q B are included in this flow of electrons, with plastoquinol leaving Q B to participate in the next step of the light-dependent reactions.
Biosynthesis pathway of PQ-9 with intermediates in blue, enzymes in black, and additional pathways in green.