Traditionally, PPP was recommended for use in platelet aggregation studies to both adjust the platelet-rich plasma concentration, and to serve as a control.
[1] PPP may have elevated levels of fibrinogen, which has the ability to form a fibrin-rich clot once activated.
Wound healing requires cell migration and attachment, which is facilitated by this fibrin clot.
[5] As a byproduct of PRP preparation, PPP may also find use in tissue engineering applications as an autologous degradable scaffold.
This plasma portion is frequently discarded when used with PRP treatments.