The Platino Award for Best Actress (Spanish: Premio Platino a la mejor actriz/Premio Platino a la mejor interpretación femenina) is one of the Platino Awards, Ibero-America's film awards presented annually by the Entidad de Gestión de Derechos de los Productores Audiovisuales (EGEDA) and the Federación Iberoamericana de Productores Cinematográficos y Audiovisuales (FIPCA).

Laia Costa became the first and only actress to win this award consecutively in 2023 and 2024 for Lullaby and Un amor, respectively.

Penélope Cruz and Antonia Zegers hold the record for the most nominations in this category, each with three nods.

Following closely behind are Paulina García, Laura de la Uz, Natalia Oreiro, Ilse Salas, Emma Suárez, Dolores Fonzi, and Laia Costa, each with two nominations.

2022 nominee Penélope Cruz also received a nomination for the Academy Award for Best Actress for Parallel Mothers.