The Platino Award for Best Actress in a Miniseries or TV series (Spanish: Mejor Interpretación Femenina en Miniserie o Teleserie) is one of the Platino Awards, Ibero-America's film awards presented annually by the Entidad de Gestión de Derechos de los Productores Audiovisuales (EGEDA) and the Federación Iberoamericana de Productores Cinematográficos y Audiovisuales (FIPCA).

In 2017, the category for Best Miniseries or TV series was introduced, being followed the next year by performance categories in television productions (male lead and female lead).

Mexican actress Cecilia Suárez is the only actress who has received the award for han once winning two years in a row (2019 and 2020) for her role as Paulina de la Mora in The House of Flowers.

Suárez is also the most nominated actress in the category with three consecutive nominations followed by Spanish actresses Inma Cuesta, Candela Peña and Úrsula Corberó, with two each.

In the list below the winner of the award for each year is shown first, followed by the other nominees.