Plazomicin, sold under the brand name Zemdri, is an aminoglycoside antibiotic used to treat complicated urinary tract infections.

[2] Other severe side effects include hearing loss, Clostridioides difficile-associated diarrhea, anaphylaxis, and muscle weakness.

[5] Plazomicin is approved by the U.S. Food and Drug Administration (FDA) for adults with complicated urinary tract infections, including pyelonephritis, caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, or Enterobacter cloacae, in patients who have limited or no alternative treatment options.

In 2012, the U.S. Food and Drug Administration granted fast track designation for the development and regulatory review of plazomicin.

[15] The FDA approved plazomicin for adults with complicated UTIs and limited or no alternative treatment options in 2018.