[1][2] The early design collaboration between Henry Stanley Plummer and Franklin Ellerbe established the model for future generations of new clinic and hospital buildings.

Will and Charlie Mayo, Dr. Stinchfield, Dr. Graham, Dr. Judd, Dr. Henry Plummer, Dr. Millet, and Dr. Balfour) desire to create the first integrated private group practice.

Ray Corwin, of Ellerbe and Round, designed the building's decorative elements.

Corwin also was responsible for the design of the decorative elements found in the Chateau Theatre and Oakwood Cemetery gate.

Its 4,000-pound (1,800 kg) ornamental bronze doors nearly always stand open, symbolizing eternal willingness to accept those in medical need.